Release date: 2016-05-24 Recently, researchers from the Walter and Eliza Hall Institute published a new study in the international academic journal Leukemia, in which they explored how a new class of anticancer drugs kill cancer cells and explain cancer cells. How to produce therapeutic resistance has a certain meaning. BET inhibitors are a new class of anticancer drugs that scientists believe have good prospects for the treatment of blood cancers such as leukemias and lymphomas. BET inhibitors can inhibit tumor growth by blocking the function of the BET protein, and the BET protein family plays an important role in regulating gene expression. BET inhibitors play a significant role in delaying tumor growth, but it is unclear whether such drugs completely kill cancer cells or simply halt the growth of cancer cells. Dr. Zhen Xu, Professor David Huang, Dr. Stefan Glaser and their colleagues answered this question together and discovered potential pathways that may cause cancer cells to resist BET inhibitors during the study. During the course of drug treatment of tumors, some cancer cells that are resistant to drugs can survive and continue to grow, leading to recurrence of the disease. Dr. Xu et al. found through a series of experiments that BET inhibitors mainly kill cancer cells by promoting apoptosis, and in the process of killing lymphoma and myeloid leukemia cells, a pro-apoptotic protein called BIM plays a role. Key role. The researchers said that when cancer cells are deficient in BIM protein, the process of apoptosis is damaged, and the BET inhibitor loses the effect of killing cancer cells. This indicates that once cancer cells acquire genetic mutations that resist apoptosis, they will Loss of sensitivity to BET inhibitors may therefore survive the course of drug treatment, leading to cancer recurrence. An in-depth understanding of the mechanism of action of BET inhibitors can help researchers improve treatment strategies, such as the use of combination therapy or changes in drug dosage and treatment time to prevent drug resistance. Source: Bio Valley Puyang Linshi Medical Supplies Co., Ltd. , https://www.linshimedical.com