"Science" magazine reported on the 28th that the team led by Boston University's synthetic biologist Wilson Huang proposed a method to genetically engineer mammalian cell DNA to perform complex calculations and turn such cells into organisms. computer. They hope that new programming techniques will help cancer treatment, growing on demand, and replacing tissues in damaged parts of the body. Scientists have attempted to extend cell editing engineering from bacteria to mammalian cells to create DNA circuits that help detect and treat human diseases. However, many of these efforts have failed because complex circuits need to work stably with switches of a single genetic component, and the most common way to turn genes on or off is to bind a protein called a transcription factor to a specific gene. Adjust its expression. The problem is that these transcription factors have subtle unstable manifestations. Huang’s team abandoned transcription factors and used shear-type enzymes to switch the genes of human kidney cells. In order to design the DNA circuit, Huang's team inserted four additional DNA fragments after the start of the conventional cell machine, two of which are called recombinase fragments, which can be activated and lit to produce green fluorescence when combined with a specific drug. The protein of the cell, thus successfully controlling the DNA switch. In a report published in Nature Biotechnology, Huang's team reported that various circuits could be created to perform different logical operations by adding more recombinases to different target lines. Currently, the team has built 113 different circuits with a success rate of 96.5%. Further demonstrations demonstrate that the human cell biology sample system they designed allows the circuit to run 16 different logics in different input combinations. Low Speed Centrifuge,Glass Centrifuge Tube,Auto Lock Rotor Centrifuge,Digital Hematocrit Centrifuge Guangdong Widinlsa International Co.Ltd , https://www.gdwidinlsa.com