Japanese scientists have developed a method for isolating and identifying active compounds in botanicals, which accurately explains the role of drugs in the body. Using this technique, they have identified a variety of active compounds from traditional Chinese medicine, and can improve memory and reduce disease characteristics in Alzheimer's disease model mice. Related articles were published on Frontiers in Pharmacology on June 19. Traditional drug screening platforms are difficult to capture real active compounds Although traditional Chinese herbal medicines have been used by humans for a long time, their pharmacological effects cannot be fully explained by modern science. Many of the large amounts of compounds contained in Chinese herbal medicines have no effect on the human body, and some have significant effects. If a unilateral botanical drug can show a therapeutic effect on a disease, scientists have the goal of isolating and identifying compounds that produce effects, and see if they can be used as new drugs. In many cases, scientists have repeatedly screened crude botanical extracts in the laboratory to see if any compounds show special effects in cell or non-cell analysis grown in culture dishes. If a compound plays an active role in cells or test tubes, it may be used as a drug, and scientists will continue to experiment on animals. However, this process is a lot of work and does not explain the changes that can occur after the drug enters the body - enzymes in the blood and liver can metabolize the drug into various forms of metabolites. In addition, some parts of the body, such as the brain, are difficult to access, and only certain drugs or their metabolites can enter these tissues. Corresponding author Chihiro Tohda explains: “The candidate compounds identified by traditional drug screening platforms for botanicals are not always true active compounds because these methods ignore biological metabolism and tissue distribution. Therefore, considering these factors, our aim is Develop more efficient methods to identify real active compounds." Best hot selling men bath robe, waterproof dry robe, dry Change Robe, surf change robe, windproof cahnge robe, swim bath robe supplier.
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